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Tazarotene is a topical retinoid with proven anti-acne activity. To determine whether, like tretinoin, tazarotene can also repair facial photodamage, these investigators conducted a manufacturer-sponsored, prospective, multicenter, investigator-masked, parallel-group study. A total of 349 subjects with at least moderate facial photodamage were randomized to treatment with tazarotene cream (0.01%, 0.025%, 0.05%, or 0.1%), tretinoin emollient cream (0.050% [Renova]), or vehicle control every evening for 24 weeks. Photodamage was evaluated on a 6-point scale, and global response to treatment was measured on a 7-point scale ranging from worsening of photodamage to total resolution.
Compared with control subjects, active-treatment subjects had si…