Adding HPV DNA testing to standard cytologic screening resulted in earlier detection of CIN3+ lesions.
Human papillomavirus DNA testing is more sensitive for detecting cervical intraepithelial neoplasia (CIN) than is cytologic testing, but the efficacy of HPV testing as a screen for high-grade lesions — including CIN 3+, carcinoma in situ, and invasive cancer — is unclear. In this study, Dutch investigators randomized more than 17,000 women (age range, 29–56) from a population-based cervical cancer screening program to receive conventional cytologic testing (control) or cytologic plus HPV DNA testing. Women with high-grade squamous intraepithelial lesions (SILs) were referred for colposcopy; women with atypical squamous cells of undetermined significance, atypical squamous cells (cannot rule out high-grade SIL), low-grade SIL, or a positive …
Reviewing Author
DisclosuresConsultant/Advisory BoardAicuris; Bayer; GSK; Innovative Molecules; Merck; MAPP Biopharmaceutical (Safety Monitoring Committee)
RoyaltiesUpToDate
Grant/Research SupportNIH/National Institute of Allergy and Infectious Diseases; GSK; Moderna; Assembly Biomedical; Aicuris
Editorial BoardsSexually Transmitted Diseases; Sexually Transmitted Infections; Journal of Infectious Diseases
Leadership PositionsID Division Chiefs Community of Practice (At-Large Member)
DisclosuresConsultant/Advisory BoardAicuris; Bayer; GSK; Innovative Molecules; Merck; MAPP Biopharmaceutical (Safety Monitoring Committee)
RoyaltiesUpToDate
Grant/Research SupportNIH/National Institute of Allergy and Infectious Diseases; GSK; Moderna; Assembly Biomedical; Aicuris
Editorial BoardsSexually Transmitted Diseases; Sexually Transmitted Infections; Journal of Infectious Diseases
Leadership PositionsID Division Chiefs Community of Practice (At-Large Member)