TMP-SMX–Associated Renal Toxicity

Acute kidney injury occurred in 11% of TMP-SMX recipients but nearly always resolved after drug discontinuation.

Trimethoprim-sulfamethoxazole (TMP-SMX) is widely used to treat urinary tract and soft-tissue infections. Despite anecdotal reports indicating the possibility of TMP-SMX–associated renal toxicity, systematic investigation has been lacking.

To remedy this situation, researchers in Texas reviewed the records of consecutive male inpatients at a Veterans Affairs Medical Center who, during a 3-year period, had received TMP-SMX for ≥6 days to treat urinary tract or soft-tissue infections. All had blood urea nitrogen (BUN) and serum creatinine levels measured both ≤7 days before starting and ≤3 days after completing therapy.

Among 573 patients, 64 (11%) had increases in both BUN and serum creatinine levels that met predetermined criteria for acute k…

Reviewing Author

Thomas Glück, MD

Disclosures

Editorial BoardsConsilium Infectiorum by InfectoPharm, Infection

Thomas Glück, MD

Disclosures

Editorial BoardsConsilium Infectiorum by InfectoPharm, Infection