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Nonparalyzed patients often cough during intubation. In patients who are emerging from general anesthesia, such coughing is observed both before and after extubation and can lead to adverse effects, including hypertension, tachyarrhythmias, and increased intracranial pressure. To assess whether intratracheal administration of lidocaine before intubation reduces coughing on emergence, investigators conducted a randomized, double-blind, controlled trial in 50 women (American Society of Anesthesiologists class 1 or 2) who were undergoing elective gynecologic surgery.
Patients underwent general anesthesia with propofol, fentanyl, and rocuronium. Two minutes later, laryngoscopy was performed, and lidocaine (160 mg) or placebo was administered via…