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Although there are no immediate prospects for arresting the aging process, topical tretinoin, an effective therapy for skin damage due to sun exposure, may be the next best thing. In a double-blind, controlled trial, 40 white men 35 to 70 years old applied tretinoin cream (which is already available for acne treatment) to one arm and the vehicle cream to the other.
All 30 patients who completed the 16-week course of treatment had significant inhibition of photoaging on the treated arm. Patients who applied tretinoin to the face had improvement of photoaging there as well. The only adverse effect of the treatment was dermatitis, which occurred in 92 percent of the patients.
Whether these benefits can be sustained over a longer period is not ye…