Toxic erythema of chemotherapy (TEC) is a painful nonallergic chemotherapy-related cutaneous reaction that generally affects the acral and intertriginous areas. The reaction can range from symmetrical erythematous to dusky patches with associated erosions and/or purpura and occurs within 30 days from chemotherapy. Common implicated agents include pegylated doxorubicin, capecitabine, and 5-fluorouracil. Clinicians should know that severe TEC cases can mimic Stevens–Johnson syndrome/toxic epidermal necrolysis; histology can help to differentiate between the diagnoses.
Comment
Toxic erythema of chemotherapy (TEC) is a painful nonallergic chemotherapy-related cutaneous reaction that generally affects the acral and intertriginous areas. The reaction can range from symmetrical erythematous to dusky patches with associated erosions and/or purpura and occurs within 30 days from chemotherapy. Common implicated agents include pegylated doxorubicin, capecitabine, and 5-fluorouracil. Clinicians should know that severe TEC cases can mimic Stevens–Johnson syndrome/toxic epidermal necrolysis; histology can help to differentiate between the diagnoses.