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In the U.S., neonatal infections with community-acquired Staphylococcus aureus (CA-SA) are increasingly common, as is the proportion caused by methicillin-resistant strains (MRSA). The literature offers little guidance for managing previously healthy infants with CA-SA. To evaluate treatment recommendations, investigators reviewed their experience with CA-SA at a single center in Texas from 2001 to 2006.
They prospectively enrolled 126 CA-SA–infected infants (43 with pustules, 68 with cellulitis or abscesses, 15 with invasive infections), aged ≤30 days, who were otherwise well at symptom onset. Eighty-four of 126 isolates were MRSA. Fifteen infants were treated as outpatients (12 with pustules, 3 with cellulitis or abscess); 1 proved to have…