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Polymicrobial endometritis complicating obstetric delivery is commonly treated with intravenous broad-spectrum antibiotics followed by a short course of oral antibiotics. Previous small studies have suggested that the addition of oral antibiotics is unnecessary. This randomized, double- blind, placebo-controlled trial evaluated whether IV therapy followed by oral therapy is more effective than IV therapy alone.
One hundred thirty-six women with documented postpartum endometritis were randomized to receive either oral amoxicillin (500 mg three times daily for five days) or placebo. Seventy-six percent had delivered by cesarean. All had successful responses to broad-spectrum IV therapy (defined as resolution of symptoms, inluding fever, and ab…