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When knee osteoarthritis involves only a single compartment (i.e., medial, lateral, or patellofemoral), unicompartmental knee arthroplasty (UKA) is an alternative to total knee arthroplasty (TKA). In a previous large, nonblinded, randomized trial, UKA for isolated medial arthritis compared favorably to TKA during 10 years of follow-up.
In this new trial from Denmark — where UKA is done more frequently than in the United States and many other countries — researchers randomized 350 patients with isolated anteromedial compartment osteoarthritis to receive either UKA or TKA. Each participating orthopedist had substantial documented experience with both procedures. During the first follow-up year, patients and evaluators were blinded to th…