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Studies examining links between antidepressant use and risk for cardiovascular disease (CVD) have produced conflicting results. Because most of these studies focused on a population already diagnosed with CVD, the researchers could not determine whether CVD was driving depression and antidepressant use, and no study used a sample representative of the general population. To prospectively study this link in such a population, researchers examined 8 years of records of 14,784 participants without existing CVD from the Scottish Health Survey. The analysis compared CVD risk in antidepressant users and nonusers and controlled for factors associated with antidepressant use and CVD risk.
Rates of use were 2.2% for tricyclic antidepressants (TCAs), …