USPSTF Issues Draft Recommendations on Genetic Screening for Women with Family Histories of Breast or Ovarian Cancer

By Kelly Young

Women with a family history of breast or ovarian cancer should be screened to see whether that history poses increased risk for BRCA1 or BRCA2 mutations, according to a draft recommendation statement from the U.S. Preventive Services Task Force. Those found to be at heightened risk should receive genetic counseling and be considered for BRCA testing.

The recommendations reaffirm the group's 2005 guidelines. But since then, family-history risk stratification tools have been tested for use in primary care to help refer patients for genetic counseling. There are also more data on using medication for breast cancer prevention, on surgeries for risk reduction, and on the possible psychological effects of genetic counseling.

In addition, the USPSTF again recommends against routine BRCA screening or genetic counseling for women whose family history does not confer increased risk.

The guidelines are open for public comment through April 29.