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Although vitamin E supplementation does not reduce the likelihood of cardiovascular events, vitamin E can inhibit vitamin K–dependent clotting factors and platelet function. Accordingly, Women’s Health Study researchers investigated whether risk for venous thromboembolism (VTE) differed in female health professionals randomly assigned to receive 600 IU of vitamin E (as α-tocopherol, the most active form) every other day (19,937 women) or to receive placebo (19,939 women).
During a median follow-up of 10.2 years, there were 213 VTE events in the vitamin E group and 269 events in the placebo group (hazard ratio, 0.79; 95% confidence interval, 0.66–0.94; P=0.010). The vitamin E group also had significantly lower rates of pulmonary embolism than…