Weight Regain after Stopping Obesity Medications

Weight management medications, especially the newer generation of incretin mimetics (primarily glucagon-like peptide-1 [GLP-1]–receptor agonists), can be highly effective, but evidence to date suggests that patients who stop these medications regain weight. In this meta-analysis, researchers evaluated 37 trials of obesity medications that involved 9000 participants with an average follow-up of 32 weeks after medication cessation.