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Dengue outbreaks have expanded in size and distribution. Several recently developed dengue-control strategies involve infecting Aedes aegypti mosquitoes, the main disease vector, with wolbachia bacteria and releasing them into affected communities. Wolbachia infection impairs reproduction with wild mosquitoes and suppresses dengue virus transmission. Both males and females or males only may be used.
In this randomized study in Singapore, 15 population clusters (≈725,000 residents in total) received either male wolbachia-infected mosquitoes or no intervention. One to six infected mosquitoes per resident were released twice weekly in intervention clusters. Researchers monitored mosquito populations using traps and obtained data on confi…