What Is the Best Timing of Complete Revascularization in STEMI?

For patients presenting with ST-segment–elevation myocardial infarction (STEMI) and multivessel coronary artery disease (CAD), the ideal timing of complete coronary revascularization is unknown. In an open-label, industry-funded trial, researchers sought to determine whether immediate complete revascularization would be noninferior to a staged approach during the index admission.

Nearly 1000 adults with STEMI and multivessel CAD who had undergone percutaneous coronary intervention (PCI) for a culprit lesion were randomized to either complete revascularization during the index procedure or staged revascularization on another day during the admission. Fractional flow reserve testing was used to guide PCI for nonculprit, intermediate-sev…