Viscous vs. Nebulized Topical Steroids for Eosinophilic Esophagitis

Mucosal contact time was longer, and eosinophilic count was correspondingly lower, with an oral viscous slurry versus a nebulized formulation of budesonide.

Corticosteroids have long been considered a mainstay of therapy for eosinophilic esophagitis (EoE). They are typically administered topically, rather than systematically, as either a viscous slurry or a nebulized inhalant that is swallowed to coat the esophagus and directly target the EoE infiltration. For example, an oral viscous slurry of budesonide proved highly effective in children with EoE (JW Gastroenterol Sep 24 2010), as did nebulized and swallowed budesonide in both adolescents and adults (JW Gastroenterol Jan 28 2011). But which delivery method is more effective is unclear.

Now, investigators have conducted a single-center, randomized, controlled trial to compare the efficacy of budesonide (1 mg twice daily) swallowed as either an…

Reviewing Author

David A. Johnson, MD

Disclosures

Consultant/Advisory boardMedscape/WebMD; Pfizer; CRH Medical Corporation; Aries

EquityCRH Medical Corporation

Editorial boardsMedscape Gastroenterology

Leadership positions in professional societiesAmerican College of Gastroenterology Research Institute Board of Directors

David A. Johnson, MD

Disclosures

Consultant/Advisory boardMedscape/WebMD; Pfizer; CRH Medical Corporation; Aries

EquityCRH Medical Corporation

Editorial boardsMedscape Gastroenterology

Leadership positions in professional societiesAmerican College of Gastroenterology Research Institute Board of Directors