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Increasing evidence suggests that computed tomographic colonography (CTC) has high sensitivity for detecting colorectal cancer — comparable to optical colonoscopy for polyps ≥10 mm but inferior for polyps <10mm (JW Gastroenterol Sep 17 2008 and JW Gastroenterol May 18 2012. The first randomized, controlled trial to directly compare laxative-free CTC and colonoscopy in a screening population found better participation for CTC but higher yield of advanced neoplasia for colonoscopy in actual participants (Lancet Oncol 2012 Jan; 13:55). Now, investigators in the U.K. have conducted a second randomized trial of CTC versus colonoscopy to compare the frequency of additional colonic investigation required in patients with colorectal symptoms.
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