The “bad” form of the gene implicated in Alzheimer disease is associated with better prognosis in TBI patients.
Multiple studies have demonstrated an association between the apolipoprotein E (ApoE) ϵ4 genotype and poorer outcome after traumatic brain injury (e.g., Journal Watch Psychiatry Jul 22 2004). This finding seems reasonable considering the pathophysiology of TBI, which involves amyloid deposition. However, recent studies have called this association into question. In the current study, researchers genotyped 79 individuals with moderate-to-severe TBI and assessed them at multiple time points over 3 years.
The population distribution of genotype frequencies was as expected: ϵ3/ϵ4 (18%), ϵ4/ϵ4 (2%), ϵ2/ϵ4 (1%), ϵ2/ϵ3 (9%), ϵ3/ϵ3 (70%). Having at least one ϵ4 allele and time s…
Reviewing Author
DisclosuresRoyaltiesTextbook of Traumatic Brain Injury, 2nd and 3rd editions
Editorial BoardsUpToDate; Journal of Neuropsychiatry and Clinical Neuroscience
Leadership Positions in Professional SocietiesNorth American Brain Injury Association (Board Member); National Institute on Disability, Independent Living, and Rehabilitation Research (Chair of Data Monitoring Safety Board for study of donepezil on cognition after traumatic brain injury)
DisclosuresRoyaltiesTextbook of Traumatic Brain Injury, 2nd and 3rd editions
Editorial BoardsUpToDate; Journal of Neuropsychiatry and Clinical Neuroscience
Leadership Positions in Professional SocietiesNorth American Brain Injury Association (Board Member); National Institute on Disability, Independent Living, and Rehabilitation Research (Chair of Data Monitoring Safety Board for study of donepezil on cognition after traumatic brain injury)