Antibiotic Prophylaxis for Children with UTIs

Prophylaxis was associated with a modest but significant reduction in recurrent UTI.

Recent studies have suggested that antibiotic prophylaxis following urinary tract infection (UTI) in children does not reduce the incidence of UTIs, but these studies had numerous shortcomings (JW Pediatr Adolesc Med Aug 8 2007 and JW Pediatr Adolesc Med Jun 11 2008). In a multicenter clinical trial, investigators in Australia randomized 576 children younger than 18 years (median age, 14 months; 64% female) with histories of culture-proven UTI to receive either low-dose antibiotic prophylaxis (2 mg/kg of trimethoprim plus 10 mg/kg of sulfamethoxazole) or placebo for 12 months.

During the 12-month study, children who received antibiotics were significantly less likely to develop a recurrent UTI than children who received placebo (13% vs. 19%;…

Reviewing Author

Howard Bauchner, MD

Disclosures

Grant / research supportHuman Resources and Services Administration; NIH; NIH-NHLBI; USDA; GlaxoSmithKline

Editorial boardsArchives of Disease in Childhood (Editor-in-Chief)

Howard Bauchner, MD

Disclosures

Grant / research supportHuman Resources and Services Administration; NIH; NIH-NHLBI; USDA; GlaxoSmithKline

Editorial boardsArchives of Disease in Childhood (Editor-in-Chief)

Antibiotic Prophylaxis for Children with UTIs

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Reviewing Author