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Male circumcision can reduce the risk for heterosexually acquired HIV infection (AIDS Clin Care Mar 19 2007), but does it benefit men who have sex with men (MSM)? To address this question, researchers performed a meta-analysis using results from 15 observational studies (conducted between 1989 and 2007) involving 53,567 MSM in the Americas, Europe, Australia, and Asia. The prevalence of circumcision was 52% overall but varied dramatically across studies (4%–88%).
The odds of being HIV-infected were not significantly lower among men who were circumcised than among those who were not (odds ratio, 0.86; 95% confidence interval, 0.65–1.13). Similar results were seen for MSM who engaged exclusively or primarily in insertive (rather than receptive…