Cumulative PI Exposure and Risk for Sudden Death or Nonhemorrhagic Stroke

A modest association was seen, but too few events occurred for the results to be considered definitive.

In early 2010, the DAD study group reported that cumulative exposure to protease inhibitors (PIs) was significantly associated with an increased risk for myocardial infarction (JW AIDS Clin Care Feb 1 2010). Now, given reports linking PIs to cardiac-conduction abnormalities (i.e., prolonged QTc and PR intervals), DAD investigators have evaluated the association between PI use and the risk for sudden cardiac death or nonhemorrhagic stroke (a composite endpoint).

Approximately 50,000 patients were followed for a total of 235,000 person-years. During that time, 78 sudden deaths and 172 nonhemorrhagic strokes occurred (and were centrally validated using standard case definitions), for incidence rates of 0.33 and 0.73 per 1000 person-years, respe…

Reviewing Author

Keith Henry, MD

Disclosures

Consultant/Advisory BoardViiV Advisory Board

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes

Keith Henry, MD

Disclosures

Consultant/Advisory BoardViiV Advisory Board

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes

Cumulative PI Exposure and Risk for Sudden Death or Nonhemorrhagic Stroke

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Reviewing Author