Adverse Effects of Currently Prescribed Antiretrovirals

Exploration of metabolic, renal, and cardiovascular effects continued at CROI 2012.

Currently recommended antiretrovirals are generally better tolerated and safer to use than older HIV drugs, but concern remains about a range of adverse effects (metabolic, cardiac, and renal) when these agents are used long-term. Data presented at CROI 2012 addressed some of these concerns.

PIs and Cardiovascular Risk

Previous studies, including the DAD Study (JW AIDS Clin Care Feb 1 2010), have shown an association between older protease inhibitors (PIs; lopinavir and indinavir) and increased risk for coronary heart disease. However, a new analysis from the DAD study, focusing on atazanavir and risk for myocardial infarction (MI) or stroke, suggests that this may not be a class-wide effect: During nearly 280,000 person-years of follow-up (i…

Author

Keith Henry, MD

Disclosures

Consultant/Advisory BoardViiV Advisory Board

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes

Keith Henry, MD

Disclosures

Consultant/Advisory BoardViiV Advisory Board

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes

Adverse Effects of Currently Prescribed Antiretrovirals

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