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Long-term use of aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with a reduction in colorectal cancer (CRC) incidence and a reduced risk for adenomatous polyps (JW Gastroenterol Mar 28 2008). However, uncertainty remains about the dose and duration of use required for NSAIDs to provide a benefit.
To address this issue, researchers in Scotland prospectively studied aspirin use in 2279 patients with newly diagnosed CRC and 2907 matched controls from the general population. Low-dose aspirin (75 mg) was used by 15.5% of CRC patients and by 18.1% of controls.
Use of low-dose aspirin was associated with diminished risk for CRC, which was evident after 1 year and significant after 5 years (P=0.004 for trend). The effect…