Long-Term Morbidity and Mortality with NAFLD and Advanced Fibrosis

At 7 years of follow-up, about 20% of patients with NAFLD developed liver complications and 13% died or received a transplant. Adjusted outcomes were favorable compared with similar patients with HCV infection.

Although nonalcoholic fatty liver disease (NAFLD) is common, few studies characterize its long-term outcomes (JW Gastroenterol Apr 3 2009 and JW Gastroenterol Jan 19 2007). Even less is known regarding the prognosis of patients with NAFLD and advanced fibrosis or how the natural history of NAFLD compares with other common liver diseases, such as chronic hepatitis C virus (HCV) infection.

To explore these issues, an international collaborative of researchers prospectively studied 247 patients with biopsy-proven NAFLD and 264 patients with HCV infection. All patients had Child-Pugh Class A with biopsy-confirmed advanced fibrosis or cirrhosis. Those comprising the HCV cohort were treatment naive or had failed treatment. Outcomes of interest inc…

Reviewing Author

Atif Zaman, MD, MPH

Disclosures

Nothing to disclose

Atif Zaman, MD, MPH

Disclosures

Nothing to disclose

Long-Term Morbidity and Mortality with NAFLD and Advanced Fibrosis

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Reviewing Author