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Some patients who undergo ileal pouch anal anastomosis develop Crohn disease in the ileal pouch. Several studies have demonstrated the efficacy of infliximab in the management of this disease (JW Gastroenterol Nov 25 2003). The current open-label trial tested the efficacy of adalimumab in 48 patients treated at a center with extensive experience in management of pouch diseases.
Patients received adalimumab using the standard regimen for ulcerative colitis or Crohn disease. Six patients had received prior treatment with infliximab and experienced either infusion reactions or no response. The majority of patients received other medical therapies concomitant with adalimumab, and about half of patients underwent endoscopic therapies, including e…