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In a previous report from the randomized Women's Health Initiative Memory Study (WHIMS), combined hormone therapy (conjugated equine estrogen [CEE] plus progestin) was associated with an increased risk for dementia and cognitive decline, compared with placebo (Journal Watch Jun 13 2003). Now, the WHIMS researchers present analogous findings for 2947 women with prior hysterectomy (age range, 65-79) who received CEE alone or placebo.
Mean follow-up was about 5 years. CEE-alone recipients showed a nonsignificant increase in risk for dementia compared with controls; the increase became statistically significant when data from the CEE-alone and CEE-plus-progestin arms of the study were combined. Findings were similar, although not statistically s…