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When sequencing of the human genome was first reported in 2001, few people imagined that they would, during their lifetimes, see the long-fantasized world of “personalized medicine,” in which each person’s entire genome realistically could be determined. However, new technologies for “massively parallel” rapid sequencing of genomes were first reported in 2005 (Journal Watch Dec 30 2005). The technologies involve shattering the genome into millions of pieces and simultaneously sequencing the bases in each piece. The sequence of each piece is entered into a computer, which knits the sequences together into a whole genome.
A team from Baylor College of Medicine used one rapid sequencing machine to sequence the entire genome of one human being: …