Loading...
Several years ago, U.S. researchers published a biopsy-based case series that involved 71 patients with obesity-related glomerulopathy (ORG), which is characterized by glomerular enlargement, frequent (but not universal) presence of focal segmental sclerosis, and substantial proteinuria (JW Apr 27 2001). An increasingly recognized association between obesity and kidney disease is the subject of three new reports.
A case series from China involved 90 obese patients who had renal biopsy findings consistent with ORG; no patients had diabetic or hypertensive nephropathy. Mean 24-hour urine protein excretion was 1.5 g. Mean serum creatinine level was 0.9 mg/dL, and about half the patients had elevated creatinine clearance, suggesting that hyperfi…