Meningococcal Vaccine Is Not Associated with Nephrotic Syndrome Relapse

Risk for relapse was not increased during the 6 months after meningococcal vaccination.

The U.K. Committee on Safety of Medicines issued a warning about an increased risk for relapse in children with steroid-responsive nephrotic syndrome during the 6 months after immunization with meningococcal C conjugate vaccine (MCCV). The warning followed publication of a U.K. study in which the risk for nephrotic syndrome relapse was nearly doubled after MCCV (Journal Watch Pediatrics and Adolescent Medicine Sep 8 2003). To independently examine this risk, investigators conducted a population-based study of 162 cases of nephrotic syndrome relapse in 53 children (age range, 1–16 years) with steroid-responsive nephrotic syndrome.

Most relapses occurred during the second and third year of life. Only 25 relapses occurred 6 months after vaccina…

Reviewing Author

F. Bruder Stapleton, MD

Disclosures

Consultant/Advisory BoardCareer Physician

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesAmerican Society of Pediatric Nephrology Foundation (Chair)

F. Bruder Stapleton, MD

Disclosures

Consultant/Advisory BoardCareer Physician

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesAmerican Society of Pediatric Nephrology Foundation (Chair)