Loading...
Calcium supplements often are recommended for preventing osteoporosis. Observational studies suggest that high calcium intake can protect against vascular disease, whereas one 5-year randomized controlled trial (RCT) indicated that women who take calcium supplements might have excess risk for myocardial infarction (MI; JW Womens Health Feb 7 2008). To evaluate further the relation between calcium supplements and cardiovascular risk, investigators performed a meta-analysis of 11 RCTs involving calcium supplementation (≥500mg daily) without vitamin D in 12,000 men and women aged >40.
During follow-up, risk for incident MI rose by 31% in participants who received calcium supplements compared with those who received placebo (hazard ratio, 1.31; …