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About 15 years ago, researchers demonstrated that a delay between taking bowel preparation and performance of colonoscopy worsened the quality of cecal and ascending colon preparation (Dis Colon Rectum 1998; 41:1223). Subsequently, many studies have confirmed that administration of half (i.e., split dosing) or all (i.e., same-day dosing) of the preparation on the day of colonoscopy provides superior bowel preparation, particularly in the ascending colon, compared with evening-before dosing (JW Gastroenterol Sep 28 2012). Split or same-day dosing has been endorsed by the American College of Gastroenterology and the U.S. Multi-Society Task Force on Colorectal Cancer as the optimal means of bowel preparation for colonoscopy.
Now, the same group…