What Mattered Most in 2025

In 2025, NEJM Journal Watch — now NEJM Clinician — covered many studies that influenced your clinical practice. At the close of each year, we ask a simple question: What research had the greatest impact on clinical practice? (See Figure 1) The result is our Year in Review — a curated set of topics that, in our view, represents the most valuable research this year. The 10 topics below represent research and guidelines that we believe every generalist clinician — and every specialist who wants to keep up with general medicine — should know as they head into 2026. For those of you who prefer to watch or listen, we prepared a special extended episode of Clinical Conversations.

• Updates in Hypertension Management

• New Insights on Extended VTE Prophy…